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17β-estradiol inhibits interleukin-1β-induced rat nucleus pulposus cell apoptosis through the PI3K/Akt/mTOR signal pathway / 生理学报
Hong-Tao GUO; Er-Fei GUO; Jian-Jie XU; Bin ZHANG; Yan-Bing GAO; Jian-Zhong WU.
Acta Physiologica Sinica ; (6): 62-68, 2021.
Article in Chinese | WPRIM | ID: wpr-878236

ABSTRACT

The apoptosis of nucleus pulposus cells (NPCs) is the main cellular process of intervertebral disc degeneration (IVDD). Our previous studies showed that 17β-estradiol (E


Subject(s)
Animals , Rats , Apoptosis , Estradiol/pharmacology , Glycogen Synthase Kinase 3 beta , Interleukin-1beta , Nucleus Pulposus/metabolism , Phosphatidylinositol 3-Kinases/metabolism , Proto-Oncogene Proteins c-akt/metabolism , Signal Transduction , TOR Serine-Threonine Kinases
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